On July 27, 1921, at the University of Toronto School of Medicine in Canada. Frederick Banting and his assistant, Charles Best. The same day, a pancreas was taken to a dog. Banting came to the judgment that the active hormone on the sugar was produced by the pancreas and made an experiment to prove this judgment. His success in this experiment proved to be a source of health for millions of diabetic patients. The first person to be treated with insulin was a 14-year-old diabetic patient, Leonard Thompsoh, on January 11, 1922, at the Toronto General Hospital, Dr. Walter Ü.Champbell and Dr. Insulin therapy was administered by Alma A. Fletcher. Since the disease was at a very advanced stage, Thompson had little chance of surviving when brought to the hospital. Thanks to insulin, he started to live a normal life again. Paul Langerhans, a medical student in Berlin in 1869, studied the structure of the pancreas with a microscope and found cell clusters that had been spread over the external secretion (exocrine) tissue of the pancreas and had not been identified before. After a while, Eduard Laguesse suggested that the latter might be producing a secretion in the digestive tract for those cells whose function is unknown at that time, which would be called “Langerhans islets”. In 1889, a Polish-born German medical doctor Oscar Minkowski, in collaboration with Joseph von Mehring, produced a healthy dog pancreas to demonstrate this predicted role of the pancreas on digestion. A few days later, it was discovered by Minkowski’s animal carer that flies were flying over the dog’s urine, and when the dog’s urine was tested it turned out to be sugar. This is the first finding that reveals the relationship between pancreas and diabetes. In 1901 another important step was taken by Eugene Opie’s relationship between the islets of Langerhans and diabetes with the statement that “the cause of diabetes is the destruction of the Langerhans islets and only these islands are partially or completely destroyed”.
Over the next 20 years, many studies have been done to collect the secretions of islets and use them as medicines. In 1906, George Ludwig Zuelzer partially succeeded in recovering dogs with pancreas extracts, but could not continue to work.
Between 1911 and 1912, EL Scott of Illinois University used diluted pancreatic extracts and noted a slight decrease in glycoside
In 1919, Israel Kleiner from Rockefeller University showed similar influences, but he did not repeat his work with the reason of World War I.
However, in 1923 the Nobel Prize committee, ins s of the University of Toronto because they find a useful method for obtaining a reward team has found suitable. Share Information You multiply